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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?

A) Chi-square is not the appropriate statistical test.
B) The sample size is inadequate to allow clinical conclusions.
C) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
D) Antihistamines should be administered to all children with otitis media who meet study entry criteria.

2. Two antihypertensive regimens have been compared in 50 patients with mild hypertension.
Treatment A decreased mean diastolic blood pressure to 81 mm Hg, and Treatment B decreased it to 85mm Hg (p = 0.08, a priori critical a = 0.05). The most reasonable interpretation of these results is that the difference between treatments is:

A) Statistically but not clinically significant.
B) Neither statistically nor clinically significant.
C) Statistically and clinically significant.
D) Clinically but not statistically significant.

3. A pharmacotherapy specialist wishes to investigate the impact of thiazolidinedione therapy on Weight gain. The specialist will determine average body weight immediately before participants begin therapy with pioglitazone and again after they complete 12 weeks of treatment. Which of the following statistical methods is most appropriate for analyzing these data?

A) Fisher's exact test
B) Paired t test
C) Unpaired t test
D) Chi-square test

4. A 54-year-old male patient (BSA = 1.8 m2) is being treated for head and neck cancer with the following regimen:
* Cisplatin 100 mg/m2 intravenously on day 1
* 5-Fluorouracil 1000 mg/m2 intravenously by continuous infusion on days 1 through 5
* Ondansetron 16 mg intravenously
Which of the following is the appropriate administration instruction for ondansetron?

A) One dose 30 minutes before Cisplatin and a repeat dose immediately before 5- fluorouracil on day 1; then repeat daily before 5-fluorouracil
B) Thirty minutes prior to Cisplatin, thereafter as needed for nausea
C) Daily prior to 5-fluorouracil infusion on days 1 through 5
D) Thirty minutes before Cisplatin on day 1

5. After the first intravenous bolus dose of a drug, the peak concentration is 50 mcg/mL, the elimination rate constant is 0.3/h, and the dosage Interval is 6 hours. Assuming a one compartment model and intravenous bolus injection, which of the following will be the peak concentration following the second dose?

A) 58 mcg/mL
B) 64 mcg/mL
C) 50mcg/mL
D) 75 mcg/mL

Solutions: